One thing to check is if the clicks are part of the file, or part of the playback. Look very closely at the wave forms and see if the clicks are drawn in the wave forms. If the clicks are visible, then it is NOT a problem with your CPU, but rather an issue in your input chain (Room, mic, cable, pre, a/d). If the clicks are not visible then the problem is in your playback chain (Hard drive, cpu, D/A, cable, speakers). If it's visible, Zoom in on it, and post a screen shot here. If it is not visible, Look at the counter in Reaper (the black box with the clock in it). If it is flashing red then you are overloading the CPU. If it is not, check the performance monitors in task manager and see if you're overloading anything. Also, loop a section and see if it clicks in the same spot each time, or at randome. [Edit] Sorry to post a lot of the same info as drybij, we appear to have posted at the same time.